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Relationship from urinary salt and you may potassium excretion having systolic blood pressure level about Weight loss Answers to End Blood pressure levels Sodium Trial

By 12 de mayo de 2022 No Comments

Relationship from urinary salt and you may potassium excretion having systolic blood pressure level about Weight loss Answers to End Blood pressure levels Sodium Trial

The 2019 National Academy of Science, Engineering and Medicine Dietary Reference Intakes (DRI) for Sodium (Na + ) and Potassium (K + ) Report concluded there remains insufficient evidence to establish a K + DRI. This study tested the hypothesis that reduced Na + and increased K + excretion will positively associate with lower blood pressure in salt sensitive (SS) and salt resistant (SR) participants in the Dietary Approaches to Stop Hypertension Sodium Trial (DASH–Sodium). Via the NHLBI BioLINCC we accessed the DASH-Sodium dataset for data on systolic blood pressure (SBP), 24-h urinary Na + and K + excretion at screening (regular patient diet; N = 186, SS N = 222 SR) and post DASH diet (N = 71 SS, N = 119 SR). The relationships between SBP, urinary Na + and K + excretion, and Na + /K + ratio were assessed via linear regression. At screening elevated urinary Na + excretion positively associated with SBP in SS (1 g increase in urinary Na + excretion = +1 0 ± 0.4 mmHg) but not SR participants, and urinary K + excretion of <1 g K + /day was associated with higher SBP in SS and SR participants. Urinary K + excretion ?1 g/day, or a decreases in urinary Na + /K + ratio, was not associated with lower SBP. Post the DASH–sodium diet intervention, SBP was reduced in SS and SR participants. However, no correlation was observed between reduced SBP and urinary K + excretion or the urinary Na + /K + ratio irrespective of the salt sensitivity of blood pressure. Our data support the DRI recommendation not to establish a K + DRI and suggest further evidence is required to support a reduced Na + /K + ratio to lower SBP.

Introduction

Blood pressure, the most used non-communicable state international, is short for a life threatening global public ailment. In accordance with the 2017 Western Center Association (AHA) guidance, this new incidence out of blood pressure in our midst adults is actually projected to be 46% ; likewise,

50% of hypertensive everyone is estimated are sodium painful and sensitive (SS) . Once the indexed by National Cardio to possess Chronic Disease Cures and Health Promotion declaration

90% off Western adults consume too much weightloss salt (Na + ), with an average day-after-day application surpassing 3400 mg when you look at the mature You people, a respect nearly 3 x the brand new day-after-day application demanded from the AHA plus the Federal Academy from Science, Technologies, and Medicine Diet Site Intakes (DRI) . Because an excessive amount of slimming down Na + consumption, that drive the newest salt susceptibility out of blood pressure level while increasing hypertension risk, global dieting Na + consumption are a community wellness exposure. New effect away from fat reduction Na + intake on the blood pressure levels has been examined for the multiple weight-loss input samples generating research you to reduced diet sodium consumption from inside the managed setup results in decreases in the blood circulation pressure [six,seven,8]. Then, meta-analyses provides coordinated weight-loss Na + restriction having decrease inside blood pressure levels indicating there was a health work for both in normotensive and you will hypertensive somebody irrespective of the brand new sodium awareness off blood pressure [nine, 10].

Connection away from urinary sodium and potassium removal that have systolic blood pressure levels in the Weightloss Remedies for Avoid Blood pressure Salt Demonstration

Recent evidence suggests the salt sensitivity of blood pressure may be modulated, in part, by dietary potassium (K + ) intake. Increasing dietary K + intake appears to counteract the effects of dietary Na + intake on increasing blood pressure [11,12,13]. Despite several studies that have documented blood pressure lowering effects of increasing K + intake, the 2019 National Academy of Science, Engineering, and Medicine DRI for sodium and potassium Report did not establish a DRI for K + . This report concluded that more evidence is required to support a DRI of K + with particular reference to a lack of K + dose-response trials limiting the evidence to establish a K + DRI . Several studies have reported that the urinary Na + :K chatki + ratio has a stronger association with blood pressure than Na + or K + independently [14, 15]. Largely based on these data, a urinary Na + to K + molar ratio of <1 has been recommended [16, 17] as a beneficial target to improve long-term blood pressure control. Given the high global dietary Na + intake this would necessitate dietary, or other means, of K + supplementation-for which a DRI has not been established . A leading dietary intervention study was the Dietary Approaches to Stop Hypertension 2 Trial (DASH-Sodium) conducted between 1997 and 2002 . The DASH-Sodium trial was a multicenter, randomized clinical trial that examined the impact of three levels dietary Na + intake in combination with either a control or DASH diet (rich in fruits, vegetables, and low-fat dairy products, and reduced in total fat) on blood pressure. This study demonstrated substantial effects of dietary Na + reduction and the DASH diet on reducing blood pressure, with more significant blood pressure lowering effects with the combination of a DASH diet plus dietary Na + reduction than dietary Na + restriction alone in individuals with higher than optimal blood pressure . Given that the DASH diet intervention elevated dietary K + intake by increasing dietary intake of fruits and vegetables in combination with modifying daily dietary Na + intake, examining the potential interaction between dietary Na + and K + intake on blood pressure in the DASH trial will provide valuable insight into the potential influence of dietary K + on blood pressure.

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